Bulk Ferulic Acid Powder Supplier:

Guanjie Biotech has focused on bulk ferulic acid powder. We have independent research and development center to promise the quality of Pure Ferulic Acid Powder. In order to promise its quality, our testing center test Ferulic acid by HPLC and other methods.

Why Choose Guanjie Biotech?

● High Quality：

The pyridine content was not detected. High crystallinity, white color.

● Free sample: 

Free sample available for quality approval.

●After sales service: 

Professional and efficient after-sale service.

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What is Ferulic Acid?

The ferulic acid is 4-hydroxy-3-methoxycinnamic acid. Its structure is a cinnamic acid derivative. As a classical phenolic acid compound, it has both phenolic structures in its structure. It also has an acid structure. And it is this unique chemical structure that determines its unique temperament and efficacy.

In 1866, scientists Barth and Hlasiwetz extracted an organic acid from the resin of the plant called ferula. It was named ferulic acid.

Structure:

The phenolic hydroxyl group and the unsaturated side chain determine that it is relatively active and has antioxidant activity. Ferulic acid has a phenolic acid structure with unsaturated double bonds and hydroxyl groups. Ferulic acid was found to have a strong reducing power for Fe3+. The relative reducing power is two times that of VC. It can effectively inhibit spontaneous and Fe2+-induced lipid peroxidation of liver homogenate.

The structure of ferulic acid is similar to half of the structure of tetrahydrocurcumin. Two ferulic acid structural formula is similar to tetrahydrocurcumin. Ferulic acid has anti-inflammatory and whitening effects.

Ferulic acid is chemically known as 4-hydroxy-3-methoxycinnamic acid. It is similar to the sunscreen agent ethylhexyl methoxycinnamate. It is for the absorption of ultraviolet rays and the role of sunscreen.

Ferulic acid usually have cis and trans two kinds. Cis is a yellow oil. The trans-type is white to slightly yellow oblique square crystals. In nature, generally trans structure exists. Cosmetics are mainly used in the trans structure.

Ferulic Acid Stability:

• Solubility:

The solubility is 0.43 mg in 100 g of hot water at 72 °C. The solubility is 0.006 mg in 100 g of cold water at 10.3 °C. However, ferulic acid is easily soluble in organic solvents such as methanol and acetone. It is easily decomposed by heat and isomerised by light.

• Ferulic acid is prone to isomerisation and yellowing.

Ferulic acid is firstly degraded by decarboxylation step to form 4-hydroxy-3-methoxystyrene. In addition, ferulic acid and 4-hydroxy-3-methoxystyrene react further. This results in the formation of a trans-conjugated dimer of 4-hydroxy-3-methoxystyrene. This is the reason for the yellowing and discolouration of cosmetics containing ferulic acid.

• pH and temperature are critical to the stability of ferulic acid.

Alkaline conditions and high temperatures dramatically accelerate the degradation of ferulic acid; at low pH, ferulic acid remains essentially stable in solution; at high pH, ferulic acid degradation is accelerated and coloured products are produced. At the same time, metal ions play a role similar to that of a catalytic centre in the degradation of ferulic acid. It will accelerate the degradation of ferulic acid. Although triethanolamine does not have similar properties, but the accelerating effect is stronger. In addition, ferulic acid is incompatible with phenoxyethanol and octylglycol.

To improve the stability of ferulic acid, it is important to keep the temperature as low as possible, to keep the pH low, and to avoid the use of metal ions and triethanolamine. In addition, the stability of ferulic acid in alcoholic solutions is much greater than in aqueous alcoholic solutions. The solvent dipropylene glycol can improve the stability of ferulic acid.

Effects:

• Whitening:

Ferulic acid has an inhibitory effect on melanin synthesis and tyrosinase activity in B16F10 melanoma cells. And the effect is more obvious with increasing dose. Protein imprinting analysis also showed that ferulic acid has a significant inhibitory effect on the expression of MITF.

• Antioxidant:

Ferulic acid is an excellent antioxidant, which is mainly due to the hydroxyl and methoxyl groups attached to the benzene ring to enable the termination of free radical chain reaction. At the same time, ferulic acid is a good free radical scavenger, inhibitor of catalase and enhancer of scavenging enzyme activity. The mechanism of ferulic acid's antioxidant activity is through the formation of stable phenoxy radicals by reacting with free radical molecules. The complex cascade of reactions generated by free radicals is difficult to initiate. Ferulic acid also acts as a hydrogen donor, directly supplying atoms to free radicals and protecting cell membrane lipoic acid from oxidation.

• Anti-Aging:

The main pathway by which ferulic acid inhibits collagen breakdown is by inhibiting the expression of matrix metalloproteinase-1 (MMP-1) and increasing the expression of matrix metalloproteinase inhibitor-1 (TIMP-1). The anti-aging effect is then achieved by inhibiting the extracellular matrix and MMP-1 and matrix metalloproteinase-9 (MMP-9) activity, and increasing the production of precollagen and hyaluronic acid in the extracellular matrix of fibroblasts.

• Anti-inflammatory:

Ferulic acid inhibits the expression of NLRP3 inflammatory vesicles and achieves anti-inflammatory and anti-radiation effects through the NLRP3-Caspase-1-IL-18-IL-1β pathway, thus significantly reducing radioactive skin damage.

• UV absorber:

Ferulic acid has a certain UV absorption effect, it can absorb the UV wavelength of 290~330 nm, covering the wavelength of UVB, ferulic acid and a variety of sunscreens used in conjunction with the synergistic effect.

Ferulic acid is effective as long as it is added in amounts greater than 0.1%. The amount of ferulic acid added in efficacy products is generally between 0.1-1%. 0.5% ferulic acid, 15% Vitamin C and 1% Vitamin E in CEF combination products have synergistic and stabilising effects.

Ferulic acid has good skin physiological effects such as whitening, anti-aging, antioxidant and anti-inflammatory. The application of ferulic acid in cosmetics is limited by the unstable nature of ferulic acid, poor water and fat solubility and its effect on formulation, and low bioavailability. For the secondary development of ferulic acid, improving its solubility, stability and transdermal properties are the focus of future development.