Oxymatrine Powder
Appearance:White powder
Specification:98%
CAS No.:519-02-8
Molecular Formula:C15H24N2O
Test method: HPLC Properties
Soluble in water, benzene, chloroform, methanol, ethanol.
Two Factories & Three production lines
Oxymatrine Powder Supplier:
Guanjie Biotech has focuses on oxymatrine powder producing and trading for 20 years. Our pure oxymatrine powder is white or off-white crystalline powder, odourless, bitter taste with the assay of 98%. We use the HPLC testing method to ensure its purity. High quality. Welcome to enquiry:info@gybiotech.com.
COA:
ANALYSIS | SPECIFICATION | RESULTS |
Assay | ≥98% | 98.31% |
Physical & Chemical Control | ||
Identification | Positive | Complies |
Appearance | white column with ridges form crystal | Complies |
Taste | Characteristic | Complies |
Loss on Drying | ≤3% | 1.51% |
Ash | ≤5% | 2.17% |
Heavy Metal | <10ppm | 0.50ppm |
Melt point | 205℃~210℃ | 209.0℃ |
Residual Solvents | Eur.Pharm. | Complies |
Pesticides | Negative | Negative无 |
Microbiology | ||
Total Plate Count | <1000CFU/gm | Complies |
Yeast & Mold | <100CFU/gm | Complies |
E.Coli | Negative | Complies |
Salmonella | Negative | Complies |
Conclusion | Conform with specification | |
Storage | Store in cool & dry place. Do not freeze.Keep away from strong light and heat. | |
Shelf life | 2 years when properly stored |
Quality Control:
In order to ensure the quality and safety of oxymatrine powder, Guanjie Biotech strictly controls the production quality. We have carried out strict quality control. The quality control mainly includes the following aspects.
• Raw material control
We choose high quality picrasidine root as raw material. This ensures that the content of oxidised Picrasidine in the raw material meets the requirements. At the same time, the raw materials should be strictly inspected and tested to prevent unqualified raw materials from entering the production process.
• Production process control
In the production process of oxymatrine powder, we strictly control the process parameters of each link to ensure the stable quality of the product. At the same time, the hygiene management in the production process should be strengthened to prevent pollution.
• Quality Inspection
Strict quality testing is carried out on the produced bulk oxymatrine powder. This includes the testing of appearance, content, purity, impurities and so on. Only products that meet the quality standards can be sold at the factory. We can provide test reports, and we also support samples for your testing.
Source
Oxidised Picrasidine (Oxymatrine) is an alkaloid extracted and isolated from the dried root of the legume Sophora flavescens Ait. Oxymatrine has a long history of use in traditional Chinese medicine and is widely used to treat a variety of diseases. Bitter ginseng is mainly distributed in China. Its growing environment is generally sandy land or grassland on mountain slopes. Bitter ginseng plants are herbs or sub-shrubs, up to 1.5 metres tall. Its roots are cylindrical with yellow or yellow-brown skin.
Chemical Properties
• Molecular Structure
Oxymatrine is chemically known as 1,3,8-trihydroxy-N-picrasidine oxide. Its molecular formula is C₁₅H₂₄N₂O₂. The molecular weight is 264.36. The molecular structure of Picrasidine oxide contains a quinolizidine ring. There are several hydroxyl groups and a nitrogen oxide group attached to the ring. This structure determines that Picrasidine oxide has certain biological activities and pharmacological effects.
• Physical Properties
Oxymatrine powder is white or off-white crystalline powder, odourless, bitter taste. It is easily soluble in water, and also has a certain solubility in organic solvents such as ethanol and chloroform. The melting point of Picrasidine oxide is 207 - 208℃. It has a certain degree of thermal stability.
• Chemical stability
Oxymatrine bulk powder has good chemical stability under certain conditions. However, under extreme conditions such as strong acid, strong base or high temperature, decomposition or structural changes may occur. Therefore, when storing and using bulk oxymatrine, contact with strong acids, strong bases and high temperature environment should be avoided to ensure its stability and effectiveness.
Safety:
1.General Safety
Oxymatrine Powder has a good general safety profile. Clinical studies have shown that there is a low incidence of adverse reactions when patients are treated with oxymatrine. Common adverse reactions mainly include nausea, vomiting, diarrhoea and dizziness. Generally the symptoms are mild and can be relieved by themselves after stopping the drug.
2.Safety in Special Populations
• Pregnant and lactating women:
There are fewer studies on the safety of oxymatrine wholesale powder in pregnant and lactating women. Therefore, it should be used with caution in pregnant and lactating women.
• Children:
The safety and efficacy of oxymatrine in children have not been established.
• Elderly:
The physiological functions of the elderly gradually decline, and their ability to metabolise and excrete drugs decreases. Therefore, the dosage should be adjusted appropriately when using oxymatrine and adverse reactions should be closely observed.