Pterostilbene Bulk Powder Supplier:

Guanjie Biotech's pterostilbene bulk powder is white powder with the asaay of 98%. High quality and competitive price. Pterostilbene is a phenolic compound. It belongs to the same family as resveratrol and is found in fruits such as grapes and blueberries, as well as in peanuts and red wine. pterostilbene has a unique mechanism of action and function, which is why research on it is constantly advancing.

COA:

Pros:

Pterostilbene bulk powder is more bioavailable than resveratrol powder. Studies have shown that pterostilbene is four times more bioavailable than resveratrol. Increased bioavailability means that a compound is better absorbed and functions better in the body. pterostilbene performs better because:

- It is more permeable and can cross cell membranes and enter cells.

- And it is more lipophilic, meaning it is more soluble in lipids (fats).

- It has more metabolic stability.

Which is better, resveratrol or pterostilbene?

Due to the two methoxyl groups, pterostilbene has higher bioavailability than resveratrol and other stilbenes. This causes it to exhibit increased lipophilicity and oral absorption. In animal studies, the bioavailability of pterostilbene was 80%. While resveratrol had a bioavailability of 20%. This suggests that it is a superior choice. So far, the data for pterostilbene looks promising. However, it should be noted that it has been studied much less than resveratrol.

Efficacy:

• How pterostilbene affects adipose tissue (fat) to reduce belly fat

In another study conducted by the same scientists in 2018, it was found that feeding pterostilbene bulk powder to animals significantly reduced the accumulation of white adipose tissue (fat) in the abdomen (WAT). As we mentioned earlier white fat is also visceral fat is mainly hoarded in the abdominal region. Many people have trouble reducing abdominal fat. Since this fat is in the abdominal cavity, it can harm many vital organs. Such as liver, pancreas and intestines.

• Anti-fibrotic effects:

Several in vivo and in vitro experiments have shown that pterostilbene purpureus has some anti-fibrotic effects. It has the potential to be a therapeutic agent for hepatic, renal, pulmonary and cardiac fibrosis. Its anti-fibrotic mechanism involves tumour transforming factor-β1, Smads protein, Sirt1 and miR-15. Its feasibility and specific mechanism for the treatment of fibrotic diseases deserve further investigation.

• Therapeutic effects on inflammatory bowel disease:

It was found that pterostilbene purpureus could improve colonic inflammation. In a murine model of colitis, pterostilbene purpureus has been shown to have immunomodulatory activity and reduce inflammation. It could provide a potential therapeutic option for chronic inflammatory diseases, including inflammatory bowel disease.

• Antidiabetic activity of pterostilbene purpureus

In animal models, pterostilbene has been shown to reduce weight gain, blood glucose, liver fat, plasma cholesterol, obesity, and inflammatory biomarkers. Studies on pterostilbene have shown that it can improve risk factors associated with diabetes.

• Pterostilbene purpureus regulates glucose metabolism

Quintela A and other scientists found that in rats fed a high-sugar diet, concomitant feeding of pterostilbene significantly reduced body weight, pterostilbene bulk powder also improved glycaemic control, increased glucose uptake, and regulated glucose metabolism in rats fed a high-sugar diet, thereby improving glycaemic control. In another study, by studying the changes of blood glucose in diabetic rats after oral administration of pterostilbene for 2-6 weeks, it was found that pterostilbene significantly lowered blood glucose at a dose of 40mg/kg. And it can change the expression of enzymes related to sugar metabolism in cells and regulate sugar metabolism. The blood glucose of both normal and diabetic rats was significantly reduced and plasma insulin level was increased after 6 weeks of oral administration of pterostilbene purpureus.

In addition, pterostilbene can play a protective role against diabetes by reducing oxidative stress and inhibiting pancreatic β-cell apoptosis. By regulating insulin sensitivity, glycaemic control and oxidative stress, pterostilbene purpureus was able to reduce fasting blood glucose levels. Oral administration of pterostilbene membranaceus to diabetic model mice for 5 weeks significantly regulated blood glucose levels by increasing insulin secretion. And total cholesterol, triglycerides and other fatty acids were maintained at normal levels.

• Pterostilbene and Diabetes Complications

The scary thing about diabetes is not the disease itself. Rather, it is the complications it brings. Diabetic complications include vascular complications such as nephropathy, neuropathy, retinopathy and vascular complications. The results of several studies have shown that pterostilbene purpureus reduces oxidative damage and restores the redox state and the primary activity of antioxidant enzymes. It may have the potential to improve long-term diabetic complications.

• Pterostilbene can modulate cell signalling pathways.

It is able to affect a variety of signalling pathways associated with tumour cell proliferation, apoptosis and metastasis. Such as PI3K/Akt, MAPK and so on. By regulating these signalling pathways, pterostilbene bulk powder can inhibit the growth and division of tumour cells. This induces apoptosis and reduces the invasion and metastatic ability of tumour cells.

• Liver protection

The pathogenesis of chronic liver disease is complex, but disease trends follow acute hepatocellular injury to apoptosis, necrosis, inflammation and irreversible fibrosis, ultimately leading to cancer. Regardless of the etiology, however, oxidative stress is a common mediator in the progression of liver injury to sustained inflammation and fibrosis. Cumulative evidence suggests that pterostilbene purpureus may promote hepatocyte function by altering a variety of antioxidant, anti-inflammatory and anti-proliferative mechanisms.

• Neuroprotection

There is a direct correlation between the pathogenesis of neurodegenerative diseases and aging. This is a result of decreased antioxidant capacity and increased oxidative stress in the elderly. These conditions are associated with aging and the onset of these conditions exacerbates aging. Several studies have shown that consumption of antioxidant-rich berries can be effective in ameliorating this neurological deterioration.

Joseph and colleagues have experimentally demonstrated that pterostilbene purpurea is associated with neuroprotection. In their experiments, older rats taking pterostilbene performed better on cognitive and motor tasks. The antioxidant capacity of pterostilbene had a significant effect on neurological function. This result may benefit thousands of patients.

The antioxidant activity of pterostilbene bulk powder is key to inhibiting pathogenesis. Its effects on antioxidant activity and multi-organ system pathogenesis are complex. But its benefits are enormous. pterostilbene not only protects nerves, attenuates atherosclerosis, prevents haemolysis and liver disease, but also regulates DM and hyperlipidaemia. In experiments on aging, vascular disease, diabetes, and hemolysis, pterostilbene powder prevented the progressive cellular damage and dysfunction associated with disease progression by reducing oxidative stress.